Cortical gene transcription response patterns to water maze training in aged mice.

ABSTRACT:

Background

The hippocampus mediates the acquisition of spatial memory, but the memory trace is eventually transferred to the cortex. We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training.

Results

We identified genes that were differentially responsive in aged mice with accurate spatial performance during probe trials or repeated swimming sessions, relative to home cage conditions. Effective learners exhibited significantly greater activation of several pathways, such as the mitogen-activated protein kinase and insulin receptor signaling pathways, relative to swimmers. The genes encoding activity-related cytoskeletal protein (Arc) and brain-derived ne

SUBMITTER: Park SS 

PROVIDER: S-EPMC3142531 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature