Ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans.

ABSTRACT:

Background

Cell-size-control systems, coupled with apoptotic- and cell-proliferation-regulatory mechanisms, determine the overall dimensions of organs and organisms, and their dysregulation can lead to tumor formation. The interrelationship between cell-growth-regulatory mechanisms and apoptosis during normal development and cancer is not understood. The TRK-fused gene (TFG) promotes tumorigenesis when present in chromosomal rearrangements from various human-cancer types by unknown mechanisms. Apaf1/CED-4 is essential for apoptosis but has not been shown to function in cell-growth control.

Results

We found that loss of TFG-1, the TFG ortholog in Caenorhabditis elegans, results in supernumerary apoptotic corpses, whereas its overexpression is sufficient to inhibit development

SUBMITTER: Chen L 

PROVIDER: S-EPMC3142714 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature