Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.

ABSTRACT:

Background

Persistent activation of signal transducers and activators of transcription 3 (STAT3) is commonly detected in many types of cancer, including colon cancer. To date, whether STAT3 is activated and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, in colon cancer stem cells are still unknown.

Methods

Flow cytometry was used to isolate colon cancer stem cells, which are characterised by both aldehyde dehydrogenase (ALDH)-positive and CD133-positive subpopulations (ALDH(+)/CD133(+)). The levels of STAT3 phosphorylation and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, that targets STAT3 in colon cancer stem cells were examined.

Results

Our results observed that ALDH(+)/CD133(+) colon cancer cells

SUBMITTER: Lin L 

PROVIDER: S-EPMC3142799 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature