Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma.

ABSTRACT:

Purpose

Hepatitis C virus (HCV) infection can promote the development of hepatocellular carcinoma (HCC). Published data implicate the HCV core gene in oncogenesis. We tested the hypothesis that core gene sequences from HCC patients differ from those of patients without cirrhosis/HCC.

Experimental design

Full-length HCV sequences from HCC patients and controls were obtained from the investigators and GenBank and compared with each other. A logistic regression model was developed to predict the HCC risk of individual point mutations and other sequence features. Mutations in partial sequences (bases 36-288) from HCC patients and controls were also analyzed. The first base of the AUG start codon was designated position 1.

Results

A logistic regression model developed thro

SUBMITTER: Fishman SL 

PROVIDER: S-EPMC3142862 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature