Sensorimotor behavioral tests for use in a juvenile rat model of traumatic brain injury: assessment of sex differences.

ABSTRACT: Modeling juvenile traumatic brain injury (TBI) in rodents presents several unique challenges compared to adult TBI, one of which is selecting appropriate sensorimotor behavioral tasks that enable the assessment of the extent of injury and recovery over time in developing animals. To address this challenge, we performed a comparison of common sensorimotor tests in Long-Evans rats of various sizes and developmental stages (postnatal days 16-45, 35-190 g). Tests were compared and selected for their developmental appropriateness, scalability for growth, pre-training requirements, and throughput capability. Sex differences in response to TBI were also assessed. Grid walk, automated gait analysis, rotarod, beam walk, spontaneous forelimb elevation test, and measurement of motor activity using th

SUBMITTER: Russell KL 

PROVIDER: S-EPMC3142868 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature