Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.

ABSTRACT: Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wound healing. The genes comprising this fibroblast common serum response are coordinately regulated in many human tumors, allowing us to identify tumors with gene expression signatures suggestive of active wounds. Genes induced in the fibroblast serum-response program are expressed in tumors by the t

SUBMITTER: Chang HY 

PROVIDER: S-EPMC314300 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature