Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder.

ABSTRACT:

Background

Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and steady-state γ-band findings in first-degree relatives of people with ASD to assess the potential familiality of these findings in ASD.

Methods

Magnetoencephalography (MEG) recordings in 21 parents who had a child with an autism spectrum disorder (pASD) and 20 healthy adult control subjects (HC) were obtained. Gamma-band phase locking factor (PLF), and evoked and induced power to 32, 40 and 48 Hz amplitude-modulated sounds were measured for transient and steady-state responses. Participants were also tested on a number of behavioral and cognitive assessments rel

SUBMITTER: Rojas DC 

PROVIDER: S-EPMC3143088 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature