A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals.

ABSTRACT: Studies of the Y chromosome in primates, rodents and carnivores provide compelling evidence that the male specific region of Y (MSY) contains functional genes, many of which have specialized roles in spermatogenesis and male-fertility. Little similarity, however, has been found between the gene content and sequence of MSY in different species. This hinders the discovery of species-specific male fertility genes and limits our understanding about MSY evolution in mammals. Here, a detailed MSY gene catalogue was developed for the horse--an odd-toed ungulate. Using direct cDNA selection from horse testis, and sequence analysis of Y-specific BAC clones, 37 horse MSY genes/transcripts were identified. The genes were mapped to the MSY BAC contig map, characterized for copy number, analyzed for tr

SUBMITTER: Paria N 

PROVIDER: S-EPMC3143126 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature