Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates.

ABSTRACT:

Background

Brominated flame retardants (BFRs) have been in widespread use in a vast array of consumer products since the 1970s. The metabolites of some BFRs show a structural similarity to thyroid hormones and experimental animal studies have confirmed that they may interfere with thyroid hormone homeostasis. A major concern has been whether intrauterine exposure to BFRs may disturb thyroid homeostasis since the fetal brain is particularly susceptible to alterations in thyroid hormones. However, few reports on newborns have been published to date.

Objectives

To evaluate the association between BFRs and neonatal thyroid-stimulating hormone (TSH).

Methods

We studied six polybrominated diphenyl ethers (PBDEs) measured in milk samples from 239 women who were part of the "

SUBMITTER: Eggesbo M 

PROVIDER: S-EPMC3143212 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature