Reduced neurotrophin receptor tropomyosin-related kinase A expression in human granulosa cells: a novel marker of diminishing ovarian reserve.

ABSTRACT:

Objective

To determine whether human mural and cumulus granulosa cell neurotrophin and neurotrophin receptor content correlate to ovarian reserve markers.

Design

Prospective, laboratory-based study.

Setting

Academic assisted reproductive technology (ART) program.

Patient(s)

Twenty-three women undergoing ART.

Intervention(s)

Mural and cumulus granulosa cells were collected from women undergoing oocyte retrieval during ART cycles. Relative messenger RNA (mRNA) levels of neurotrophins and their receptors were measured by quantitative reverse transcription-polymerase chain reaction and correlated to serum antimüllerian hormone (AMH) levels and the number of oocytes retrieved.

Main outcome measure(s)

Number of oocytes retrieved.

Result(s)

Mural

SUBMITTER: Buyuk E 

PROVIDER: S-EPMC3143233 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature