Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women.

ABSTRACT:

Objective

To evaluate the effects of a commonly used combined hormonal oral contraceptive (OC) on carbohydrate metabolism in obese as compared with lean women.

Design

6-month prospective study.

Setting

Clinical research center at an academic medical center.

Patient(s)

Premenopausal nondiabetic women with body mass index <25 kg/m(2) (n = 15) or >30 kg/m(2) (n = 14).

Intervention(s)

Ethinyl estradiol (35 μg) and norgestimate (0.18/0.215/0.25 mg) for 6 cycles.

Main outcome measure(s)

Insulin sensitivity by frequent sampling intravenous glucose tolerance test; other indices of insulin sensitivity (homeostatic model assessment of insulin sensitivity index [ISI HOMA], the Matsuda index); fasting lipid panel.

Result(s)

Insulin sensitivity changed

SUBMITTER: Cheang KI 

PROVIDER: S-EPMC3143285 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature