Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses in the Women's Health Study.

ABSTRACT:

Background

Migraine with aura (MA) has been associated with increased risk of cardiovascular disease (CVD). The role of aspirin on this association remains unclear.

Methods

Post-hoc subgroup analyses of the Women's Health Study, a randomized trial testing 100 mg aspirin on alternate days in primary prevention of CVD among 39,876 women aged ≥ 45.

Results

During 10 years, 998 major CVD events were confirmed in 39,757 women with complete migraine information. Aspirin reduced risk of ischaemic stroke (relative risk, RR, 0.76, 95% CI 0.63-0.93) but not other CVD. Migraine or MA did not modify the effect of aspirin on CVD except for myocardial infarction (MI) (p for interaction = 0.01). Women with MA on aspirin had increased risk of MI (RR 3.72, 95% CI 1.39-9.95). Further e

SUBMITTER: Kurth T 

PROVIDER: S-EPMC3143294 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature