A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties.

ABSTRACT: Cerium oxide nanoparticles (CeNPs) have shown promise as catalytic antioxidants in cell culture and animal models as both superoxide dismutase and catalase mimetics. The reactivity of the cerium (Ce) atoms at the surface of its oxide particle is critical to such therapeutic properties, yet little is known about the potential for a protein or small molecule corona to form on these materials in vivo. Moreover Ce atoms in these active sites have the potential to interact with small molecule anions, peptides, or sugars when administered in culture or animal models. Several nanomaterials have been shown to alter or aggregate under these conditions, rendering them less useful for biomedical applications. In this work we have studied the change in catalytic properties of CeNPs when exposed to var

SUBMITTER: Singh S 

PROVIDER: S-EPMC3143296 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature