Identification of membrane associated drug targets in Borrelia burgdorferi ZS7- subtractive genomics approach.

ABSTRACT: Lyme disease is an infectious disease caused by a spirochete Borrelia burgdorferi ZS7. This spirochete is most often spread by ticks. Single antibiotic therapy is sufficient for containment of the early stage progression of the disease but combinational therapy is more preferred in later stages. Research is in progress for the development of drugs against the pathogen, but till date no vaccines have been developed to effect the late stage infections. There is a rapid rise in the cases of antibiotic-resistant population which is more than 10% of the total infected individuals. In such condition vaccine becomes the sole alternative for prevention. Therefore effective treatment includes antibiotic combination and combination of antigenic surfaces (for vaccine preparation). Thus, a comprehensi

SUBMITTER: Madagi S 

PROVIDER: S-EPMC3143400 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature