Early transcriptional responses of HepG2-A16 liver cells to infection by Plasmodium falciparum sporozoites.

ABSTRACT: Invasion of hepatocytes by Plasmodium sporozoites deposited by Anopheles mosquitoes, and their subsequent transformation into infective merozoites is an obligatory step in the initiation of malaria. Interactions between the sporozoites and hepatocytes lead to a distinct, complex and coordinated cellular and systemic host response. Little is known about host liver cell response to sporozoite invasion, or whether it is primarily adaptive for the parasite, for the host, or for both. Our present study used gene expression profiling of human HepG2-A16 liver cells infected with Plasmodium falciparum sporozoites to understand the host early cellular events and factors influencing parasite infectivity and sporozoite development. Our results show that as early as 30 min following wild-type, non-irr

SUBMITTER: Chattopadhyay R 

PROVIDER: S-EPMC3143603 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature