Assessment of anti-inflammatory tumor treatment efficacy by longitudinal monitoring employing sonographic micro morphology in a preclinical mouse model.

ABSTRACT:

Background

With the development of increasingly sophisticated three-dimensional volumetric imaging methods, tumor volume can serve as a robust and reproducible measurement of drug efficacy. Since the use of molecularly targeted agents in the clinic will almost certainly involve combinations with other therapeutic modalities, the use of volumetric determination can help to identify a dosing schedule of sequential combinations of cytostatic drugs resulting in long term control of tumor growth with minimal toxicity. The aim of this study is to assess high resolution sonography imaging for the in vivo monitoring of efficacy of Infliximab in pancreatic tumor.

Methods

In the first experiment, primary orthotopic pancreatic tumor growth was measured with Infliximab treatment. In the

SUBMITTER: Tiwari S 

PROVIDER: S-EPMC3143928 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature