TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

ABSTRACT:

Aims

TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses.

Methods

We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvement of proinsulin processing during 2.5-years of follow-up participants (N = 2,994) from the Diabetes Prevention Program (DPP), a randomized controlled trial designed to prevent or delay diabetes in high-risk adults.

Results

We observed no difference in the degree of weight loss by rs7903146 genotypes. However, the T allele (conferring higher risk of diabetes) at rs7903146 was as

SUBMITTER: McCaffery JM 

PROVIDER: S-EPMC3144193 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature