Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer.

ABSTRACT:

Background

The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pancreatic cancer.

Methods

Serum samples were collected preoperatively in patients undergoing surgery for localized pancreatic cancer (n = 74), metastatic pancreatic cancer (n = 24) or chronic pancreatitis (n = 20) and in healthy controls (n = 48). Quantitative enzyme-linked immunosorbent assays and multiplex protein arrays were used to determine circulating levels of VEGF, VEGFR-1, PlGF, PDGF-AA, PDGF-BB, Ang-1 and EGF. Multivariate analyses on cancer-specific survival were performed with a Cox proportional hazards model.

Results

VEGF (p < 0.0001), PDGF-

SUBMITTER: Rahbari NN 

PROVIDER: S-EPMC3144458 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature