Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis.

ABSTRACT:

Unlabelled

To determine the association of the Apolipoprotein E (APOE) E4 gene polymorphism with bone mineral density (BMD) and fractures we conducted a meta-analysis of 17 reports. Despite lower trochanteric and lumbar BMD in APOE4 carriers, there is insufficient evidence to support a consistent association of APOE with bone health.

Introduction

APOE has been studied for its potential role in osteoporosis risk. It is hypothesized that genetic variation at APOE locus, known as E2, E3, and E4, may modulate BMD through its effects on lipoproteins and vitamin K transport. The purpose of this study was to determine the association of the APOE-E4 gene polymorphism with bone-related phenotypes.

Methods

We conducted a meta-analysis that combined newly analyzed individual dat

SUBMITTER: Peter I 

PROVIDER: S-EPMC3144470 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature