Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities.

ABSTRACT: The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit a remarkable range of potent biological activities. Although partial activity information is available for some natural daphnanes, little information exists for non-natural congeners or on how changes in structure affect mode of action, function, potency or selectivity. A gateway strategy designed to provide general synthetic access to natural and non-natural daphnanes is described and utilized in the synthesis of two novel members of this class. In this study, a commercially available tartrate derivative was elaborated through a key late-stage diversification intermediate into B-ring yuanhuapin analogues to initiate exploration of the structure-function relationships of this cl

SUBMITTER: Wender PA 

PROVIDER: S-EPMC3144521 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature