Structures of the rat complement regulator CrrY.

ABSTRACT: Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.

SUBMITTER: Roversi P 

PROVIDER: S-EPMC3144786 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature