Parameterization and sensitivity analysis of a complex simulation model for mosquito population dynamics, dengue transmission, and their control.

ABSTRACT: Models can be useful tools for understanding the dynamics and control of mosquito-borne disease. More detailed models may be more realistic and better suited for understanding local disease dynamics; however, evaluating model suitability, accuracy, and performance becomes increasingly difficult with greater model complexity. Sensitivity analysis is a technique that permits exploration of complex models by evaluating the sensitivity of the model to changes in parameters. Here, we present results of sensitivity analyses of two interrelated complex simulation models of mosquito population dynamics and dengue transmission. We found that dengue transmission may be influenced most by survival in each life stage of the mosquito, mosquito biting behavior, and duration of the infectious period in h

SUBMITTER: Ellis AM 

PROVIDER: S-EPMC3144822 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature