Effect of gene environment interactions on lung function and cardiovascular disease in COPD.

ABSTRACT:

Background

The objective of this study was to determine if gene-environment interactions between cigarette smoking and interleukin-6 (IL6), interferon-γ (IFNG), interleukin-1β (IL1B), or interleukin-1 receptor antagonist (IL1RN) single nucleotide polymorphisms are associated with lung function decline and cardiovascular disease in chronic obstructive pulmonary disease (COPD).

Methods

Single nucleotide polymorphisms (SNPs) in IL6, IFNG, IL1B, and IL1RN were genotyped in the Lung Health Study and correlated with rate of decline of forced expiratory volume in 1 second (FEV(1)) over 5 years, baseline FEV(1), serum protein levels, cardiovascular disease, and interactions with smoking.

Results

The IL6 rs2069825 single nucleotide polymorphism was associated with the rate of

SUBMITTER: Hackett TL 

PROVIDER: S-EPMC3144847 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature