Prophylactic activated recombinant factor VII in liver resection and liver transplantation: systematic review and meta-analysis.

ABSTRACT:

Background and aim

Intraoperative blood loss is a frequent complication of hepatic resection and orthotopic liver transplantation. Recombinant activated coagulation factor VII (rFVIIa) is a coagulation protein that induces hemostasis by directly activating factor X. There is no clear information about the prophylactic value of rFVIIa in hepatobiliary surgery, specifically in liver resection and orthotopic liver transplantation. The aim of this study was to assess the effect of rFVIIa prophylaxis to prevent mortality and bleeding resulting from hepatobiliary surgery.

Methods

Relevant randomized trials were identified by searching The Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index. Randomized clinical trials

SUBMITTER: Chavez-Tapia NC 

PROVIDER: S-EPMC3144913 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature