Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination.

ABSTRACT:

Background

Major depressive disorder (MDD) has been associated reliably with ruminative responding; this kind of responding is composed of both maladaptive and adaptive components. Levels of activity in the default-mode network (DMN) relative to the task-positive network (TPN), as well as activity in structures that influence DMN and TPN functioning, may represent important neural substrates of maladaptive and adaptive rumination in MDD.

Methods

We used a unique metric to estimate DMN dominance over TPN from blood oxygenation level-dependent data collected during eyes-closed rest in 17 currently depressed and 17 never-disordered adults. We calculated correlations between this metric of DMN dominance over TPN and the depressive, brooding, and reflective subscales of the Rumin

SUBMITTER: Hamilton JP 

PROVIDER: S-EPMC3144981 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature