Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea.

ABSTRACT:

Introduction

Obstructive sleep apnea (OSA) is associated with increased risk for metabolic syndrome in both adults and children. In adults with OSA, serum levels of fatty acid binding protein 4 (FABP4) are elevated and associated with the degree of metabolic insulin resistance, independent of obesity. Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA.

Methods

A total of 309 consecutive children ages 5-8years were recruited. Children were divided into those with OSA and without OSA (NOSA) based on the apnea-hypopnea index (AHI). Subjects were also subdivided into obese (OB) and non-obese (NOB) based on BMI z score. Morning fasting plasma FABP4 levels were assayed using ELISA, and 11 single-nucleotide pol

SUBMITTER: Bhushan B 

PROVIDER: S-EPMC3144996 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature