Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions.

ABSTRACT: Epithelial cells have the ability to regulate paracellular permeability dynamically in response to extracellular stimuli. With every respiratory effort, airway epithelial cells are exposed to both physiologic as well as pathologic stimuli, and regulation of the epithelial barrier in response to these stimuli is crucial to respiratory function. We report that increased membrane septin-2 localization mediates decreases in paracellular permeability by altering cortical actin arrangement in human airway epithelial cells. This phenomenon occurs in response to both physiologic levels of shear stress and a pathologic stimulus, particular matter exposure. The resulting changes in barrier function in response to septin-2 redistribution have a significant impact on the ability of the apical ligand,

SUBMITTER: Sidhaye VK 

PROVIDER: S-EPMC3145065 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature