Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation.

ABSTRACT:

Background

Declined lung function is a risk factor for particulate matter associated respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). Carbon nanoparticles (CNP) are a prominent component of outdoor air pollution that causes pulmonary toxicity mainly through inflammation. Recently we demonstrated that mice (C3H/HeJ) with higher than normal pulmonary function resolved the elicited pulmonary inflammation following CNP exposure through activation of defense and homeostasis maintenance pathways. To test whether CNP-induced inflammation is affected by declined lung function, we exposed JF1/Msf (JF1) mice with lower than normal pulmonary function to CNP and studied the pulmonary inflammation and its resolution.

Methods

5 μg, 20 μg and 50 μg CNP (Pr

SUBMITTER: Ganguly K 

PROVIDER: S-EPMC3145576 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature