Zinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis.

ABSTRACT:

Background

Our previous studies showed that ZBTB20, a new BTB/POZ-domain gene, could negatively regulate α feto-protein and other liver-specific genes, concerning such as bio-transformation, glucose metabolism and the regulation of the somatotropic hormonal axis. The aim of this study is to determine the potential clinical implications of ZBTB20 in hepatocellular carcinoma (HCC).

Methods

Quantitative real-time RT-PCR and Western blot analyses were used to detect expression levels of ZBTB20 in 50 paired HCC tumorous and nontumorous tissues and in 20 normal liver tissues. Moreover, expression of ZBTB20 was assessed by immunohistochemistry of paired tumor and peritumoral liver tissue from 102 patients who had undergone hepatectomy for histologically proven HCC. And its relation

SUBMITTER: Wang Q 

PROVIDER: S-EPMC3145616 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature