Trans-generational epigenetic regulation of C. elegans primordial germ cells.

ABSTRACT:

Background

The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have suggested that germline continuity can involve epigenetic regulation, including regulation of histone modifications. However, it is not clear how histone modifications generated in one generation can influence the transcription program and development of germ cells of the next.

Results

We show that the histone H3K36 methyltransferase maternal effect sterile (MES)-4 is an epigenetic modifier that prevents aberrant transcription activity in Caenorhabditis elegans primordial germ cells (PGCs). In mes-4 mutant PGCs, RNA Pol II activation is abnormally regulated and the PGCs degenerate. Genetic and genomewide analyses

SUBMITTER: Furuhashi H 

PROVIDER: S-EPMC3146070 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature