Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates.

ABSTRACT:

Background

The highly pathogenic H5N1 is a major avian pathogen that intensively affects the poultry industry in Egypt even in spite of the adoption of vaccination strategy. Antigenic drift is among the strategies the influenza virus uses to escape the immune system that might develop due to the pressure of extensive vaccination. H5N1 mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences such an eventuality will entail.

Methods

H5N1 was isolated from the pooled organ samples of four different affected flocks in specific pathogen free embryonated chicken eggs (SPF-ECE). A reverse transcriptase polymerase chain reaction (RT-PCR) was performed to the haemagglutingin and neuraminidase. Seque

SUBMITTER: Abdel-Moneim AS 

PROVIDER: S-EPMC3146449 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature