Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity.

ABSTRACT:

Background

The interaction between apolipoprotein A-II (APOA2) m265 genotype and saturated fat for obesity traits has been more extensively demonstrated than for any other locus, but behavioural and hormonal mechanisms underlying this relationship are unexplored. In this study, we evaluated relationships between APOA2 and obesity risk with particular focus on patterns of eating and ghrelin, a hormonal regulator of food intake.

Design

Cross-sectional study.

Subjects

Overweight and obese subjects (n=1225) were evaluated at baseline in five weight loss clinics in southeastern Spain.

Methods

Behavioural data were assessed using a checklist of weight loss obstacles. Logistic regression models were fitted to estimate the risk of a specific behaviour associated with A

SUBMITTER: Smith CE 

PROVIDER: S-EPMC3146593 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature