Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening.

ABSTRACT: Risk prediction based on genomic profiles has raised a lot of attention recently. However, family history is usually ignored in genetic risk prediction. In this study we proposed a statistical framework for risk prediction given an individual's genotype profile and family history. Genotype information about the relatives can also be incorporated. We allow risk prediction given the current age and follow-up period and consider competing risks of mortality. The framework allows easy extension to any family size and structure. In addition, the predicted risk at any percentile and the risk distribution graphs can be computed analytically. We applied the method to risk prediction for breast and prostate cancers by using known susceptibility loci from genome-wide association studies. For breast

SUBMITTER: So HC 

PROVIDER: S-EPMC3146722 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature