Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension.

ABSTRACT:

Context

The co-occurrence of insulin resistance (IR) and hypertension is a heritable condition leading to cardiovascular complications. Caveolin-1 (CAV1), a gene previously associated with metabolic dysfunction in animal and cellular models, may be a marker for these conditions in humans.

Objective

The objective of the study was to examine the relationship between CAV1 variants and IR in two hypertensive cohorts and to corroborate the findings in a CAV1 knockout mouse.

Design, setting, and participants

A candidate gene association study was conducted in two hypertensive cohorts: 1) Caucasian and 2) Hispanic. Multivariate associations between individual variants and insulin-resistant phenotypes were analyzed, accounting for age, gender, body mass index, and sibling rel

SUBMITTER: Pojoga LH 

PROVIDER: S-EPMC3146791 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature