Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds.

ABSTRACT:

Background

The P27-P55 (lprG-Rv1410c) operon is crucial for the survival of Mycobacterium tuberculosis, the causative agent of human tuberculosis, during infection in mice. P55 encodes an efflux pump that has been shown to provide Mycobacterium smegmatis and Mycobacterium bovis BCG with resistance to several drugs, while P27 encodes a mannosylated glycoprotein previously described as an antigen that modulates the immune response against mycobacteria. The objective of this study was to determine the individual contribution of the proteins encoded in the P27-P55 operon to the resistance to toxic compounds and to the cell wall integrity of M. tuberculosis.

Method

In order to test the susceptibility of a mutant of M. tuberculosis H37Rv in the P27-P55 operon to malachite green, s

SUBMITTER: Bianco MV 

PROVIDER: S-EPMC3146831 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature