Genome-wide evidence for positive selection and recombination in Actinobacillus pleuropneumoniae.

ABSTRACT:

Background

Actinobacillus pleuropneumoniae is an economically important animal pathogen that causes contagious pleuropneumonia in pigs. Currently, the molecular evolutionary trajectories for this pathogenic bacterium remain to require a better elucidation under the help of comparative genomics data. For this reason, we employed a comparative phylogenomic approach to obtain a comprehensive understanding of roles of natural selective pressure and homologous recombination during adaptation of this pathogen to its swine host.

Results

In this study, 12 A. pleuropneumoniae genomes were used to carry out a phylogenomic analyses. We identified 1,587 orthologous core genes as an initial data set for the estimation of genetic recombination and positive selection. Based on the analyses

SUBMITTER: Xu Z 

PROVIDER: S-EPMC3146884 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature