CREST--a large and diverse superfamily of putative transmembrane hydrolases.

ABSTRACT:

Background

A number of membrane-spanning proteins possess enzymatic activity and catalyze important reactions involving proteins, lipids or other substrates located within or near lipid bilayers. Alkaline ceramidases are seven-transmembrane proteins that hydrolyze the amide bond in ceramide to form sphingosine. Recently, a group of putative transmembrane receptors called progestin and adipoQ receptors (PAQRs) were found to be distantly related to alkaline ceramidases, raising the possibility that they may also function as membrane enzymes.

Results

Using sensitive similarity search methods, we identified statistically significant sequence similarities among several transmembrane protein families including alkaline ceramidases and PAQRs. They were unified into a large and dive

SUBMITTER: Pei J 

PROVIDER: S-EPMC3146951 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature