Genetic contributions to the association between adult height and testicular germ cell tumors.

ABSTRACT:

Background

Previously, we have shown that increasing adult height is associated with increased risk of testicular germ-cell tumor (TGCT). Recently, a number of single nucleotide polymorphisms (SNPs) have been found to be related to height. We examined whether these SNPs were associated with TGCT and whether they explained the relationship between height and TGCT.

Methods

We genotyped 15 height-related SNPs in the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study. DNA was extracted from buccal cell samples and Taqman assays were used to type the selected SNPs. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs).

Results

There were 561 cases and 676 controls for analysi

SUBMITTER: Cook MB 

PROVIDER: S-EPMC3147069 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature