Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.

ABSTRACT:

Background

Elevated serum soluble E-selectin levels have been associated with a number of diseases. Although E-selectin levels are heritable, little is known about the specific genetic factors involved. E-selectin levels have been associated with the ABO blood group phenotype.

Methods and results

We performed a high-resolution genome-wide association study of serum soluble E-selectin levels in 685 white individuals with type 1 diabetes from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study to identify major loci influencing levels. Highly significant evidence for association (P=10(-29)) was observed for rs579459 near the ABO blood group gene, accounting for 19% of the variance in E-selectin levels. Levels

SUBMITTER: Paterson AD 

PROVIDER: S-EPMC3147250 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature