Short- and long-term adaptation to ethanol stress and its cross-protective consequences in Lactobacillus plantarum.

ABSTRACT: This paper describes the molecular responses of Lactobacillus plantarum WCFS1 toward ethanol exposure. Global transcriptome profiling using DNA microarrays demonstrated adaptation of the microorganism to the presence of 8% ethanol over short (10-min and 30-min) and long (24-h) time intervals. A total of 57 genes were differentially expressed at all time points. Expression levels of an additional 859 and 873 genes were modulated after 30 min and 24 h of exposure to the solvent, respectively. Ethanol exposure led to induced expression of genes involved in citrate metabolism and cell envelope architecture, as well as canonical stress response pathways controlled by the central stress regulators HrcA and CtsR. Correspondingly, cells grown for 24 h in medium containing 8% ethanol exhibited high

SUBMITTER: van Bokhorst-van de Veen H 

PROVIDER: S-EPMC3147428 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature