Novel insights into the regulation of LexA in the cyanobacterium Synechocystis sp. Strain PCC 6803.

ABSTRACT: The transcription factor LexA in the cyanobacterium Synechocystis sp. strain PCC 6803 has been shown to regulate genes that are not directly involved in DNA repair but instead in several different metabolic pathways. However, the signal transduction pathways remain largely uncharacterized. The present work gives novel insights into the regulation of LexA in this unicellular cyanobacterium. A combination of Northern and Western blotting, using specific antibodies against the cyanobacterial LexA, was employed to show that this transcription regulator is under posttranscriptional control, in addition to the classical and already-described transcriptional regulation. Moreover, detailed two-dimensional (2D) electrophoresis analyses of the protein revealed that LexA undergoes posttranslational m

SUBMITTER: Oliveira P 

PROVIDER: S-EPMC3147542 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature