Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.

ABSTRACT: Therapeutic options for tuberculosis (TB) are limited and notoriously ineffective despite the wide variety of potent antibiotics available for treating other bacterial infections. We investigated an approach that enables an expansion of TB therapeutic strategies by using synergistic combinations of drugs. To achieve this, we devised a high-throughput synergy screen (HTSS) of chemical libraries having known pharmaceutical properties, including thousands that are clinically approved. Spectinomycin was used to test the concept that clinically available antibiotics with limited efficacy against Mycobacterium tuberculosis might be used for TB treatment when coadministered with a synergistic partner compound used as a sensitizer. Screens using Mycobacterium smegmatis revealed many compounds in o

SUBMITTER: Ramon-Garcia S 

PROVIDER: S-EPMC3147639 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature