Peripheral blood signatures of lead exposure.

ABSTRACT:

Background

Current evidence indicates that even low-level lead (Pb) exposure can have detrimental effects, especially in children. We tested the hypothesis that Pb exposure alters gene expression patterns in peripheral blood cells and that these changes reflect dose-specific alterations in the activity of particular pathways.

Methodology/principal finding

Using Affymetrix Mouse Genome 430 2.0 arrays, we examined gene expression changes in the peripheral blood of female Balb/c mice following exposure to per os lead acetate trihydrate or plain drinking water for two weeks and after a two-week recovery period. Data sets were RMA-normalized and dose-specific signatures were generated using established methods of supervised classification and binary regression. Pathway activity w

SUBMITTER: LaBreche HG 

PROVIDER: S-EPMC3148235 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature