Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression.

ABSTRACT: Tumor development relies upon essential contributions from the tumor microenvironment and host immune alterations. These contributions may inform the plasma proteome in a manner that could be exploited for cancer diagnosis and prognosis. In this study, we employed a systems biology approach to characterize the plasma proteome response in the inducible HER2/neu mouse model of breast cancer during tumor induction, progression, and regression. Mass spectrometry data derived from approximately 1.6 million spectra identified protein networks involved in wound healing, microenvironment, and metabolism that coordinately changed during tumor development. The observed alterations developed prior to cancer detection, increased progressively with tumor growth and reverted toward baseline with tumor r

SUBMITTER: Pitteri SJ 

PROVIDER: S-EPMC3148311 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature