IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells.

ABSTRACT: The switch of tumor cells from an epithelial to a mesenchymal-like phenotype [designated as epithelial-to-mesenchymal transition (EMT)] is known to induce tumor cell motility and invasiveness, therefore promoting metastasis of solid carcinomas. Although multiple studies have focused on elucidating the signaling events that initiate this phenotypic switch, there has been so far no characterization of the pattern of soluble mediators released by tumor cells undergoing EMT, and the potential impact that this phenotypic switch could have on the remodeling of the tumor microenvironment. Here we show that induction of EMT in human carcinoma cells via overexpression of the transcription factor Brachyury is associated with enhanced secretion of multiple cytokines, chemokines, and angiogenic factor

SUBMITTER: Fernando RI 

PROVIDER: S-EPMC3148346 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature