A novel lead configuration for optimal spatio-temporal detection of intracardiac repolarization alternans.

ABSTRACT:

Background

Electric alternans is a pattern of variation in the shape of ECG waveform that occurs every other beat. In humans, alternation in ventricular repolarization, known as repolarization alternans (RA), has been associated with increased vulnerability to ventricular tachycardia/fibrillation and sudden cardiac death.

Methods and results

This study investigates the spatio-temporal variability of intracardiac RA and its relationship to body surface RA in an acute myocardial ischemia model in swine. We developed a real-time multichannel repolarization signal acquisition, display, and analysis system to record ECG signals from catheters in the right ventricle, coronary sinus, left ventricle, and epicardial surface before and after circumflex coronary artery balloon occlusio

SUBMITTER: Weiss EH 

PROVIDER: S-EPMC3148443 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature