Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis.

ABSTRACT:

Background

Asthma is a phenotypically diverse disease with genetic susceptibility. A single nucleotide polymorphism (SNP) in the CD14 gene at position -260 (also known as -159) C>T has been inconsistently associated with asthma. The aim of this study was to estimate the combined likelihood of developing asthma given the CD14 -260C>T genotype.

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search and meta-analysis of the literature was conducted to estimate the association between this SNP and asthma. Planned subgroup analyses were performed to detect potential sources of heterogeneity from selected study characteristics. Post-hoc sensitivity analysis was performed to identify studies exerting excessi

SUBMITTER: Zhao L 

PROVIDER: S-EPMC3148550 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature