Improved haplotype-based detection of ongoing selective sweeps towards an application in Arabidopsis thaliana.

ABSTRACT:

Background

The increasing amount of genome information allows us to address various questions regarding the molecular evolution and population genetics of different species. Such genome-wide data sets including thousands of individuals genotyped at hundreds of thousands of markers require time-efficient and powerful analysis methods. Demography and sampling introduce a bias into present population genetic tests of natural selection, which may confound results. Thus, a modification of test statistics is necessary to introduce time-efficient and unbiased analysis methods.

Results

We present an improved haplotype-based test of selective sweeps in samples of unequally related individuals. For this purpose, we modified existing tests by weighting the contribution of each individu

SUBMITTER: Gunther T 

PROVIDER: S-EPMC3148560 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature