Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling.

ABSTRACT: Alterations to the structure of the glomerular filtration barrier lead to effacement of podocyte foot processes, leakage of albumin, and the development of proteinuria. To better understand the signaling pathways involved in the response of the glomerular filtration barrier to injury, we studied freshly isolated rat glomeruli, which allows for the monitoring and pharmacologic manipulation of early signaling events. Administration of protamine sulfate rapidly damaged the isolated glomeruli, resulting in foot process effacement and albumin leakage. Inhibition of calcium channels and chelation of extracellular calcium reduced protamine sulfate-induced damage, suggesting that calcium signaling plays a critical role in the initial stages of glomerular injury. Calcineurin inhibitors (FK506 and c

SUBMITTER: Vassiliadis J 

PROVIDER: S-EPMC3148700 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature