Synthesis of the dysiherbaine tetrahydropyran core utilizing improved tethered aminohydroxylation conditions.

ABSTRACT: A concise stereoselective route to the dysiherbaine tetrahydropyran core was achieved in 9 steps and 39% overall yield. Donohoe's improved tethered aminohydroxylation conditions were employed to concurrently install the amino and alcohol groups and construct the tetrahydropyran ring, which features four contiguous cis-stereocenters.

SUBMITTER: Carroll CL 

PROVIDER: S-EPMC3148768 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature